Dr. Stephen A Smith EurChem CSci CChem FRSC

Experience:

Recent experience, working mainly with small companies and academia, has included analysis / oversight of research proposals, compound libraries and screening output, through to competitor viewpoint and helping resolve developability issues close to candidate selection.

Extensive use of informatics tools, particularly cheminformatics, facilitates decisions.

Training lectures on topics such as the likely requirements for a Clinical Candidate and the ideal Physicochemical Properties of a Drug have been given at various European locations.

Previously, almost 30 years experience of the Drug Discovery process within large Pharma included all aspects of Medicinal Chemistry from screen / HTS set-up to collaboration with Development functions post Candidate Selection.

Experience of leading / co-ordinating cross functional teams to key milestones, including Clinical Candidate decisions, in numerous therapeutic areas.

• Over 100 publications including inventorship on 40 patents.
  
• Co-inventorship and co-ordinated discovery of inhibitors of the enzyme Lipoprotein-Associated Phospholipase A2. The most advanced of these - Darapladib, SB-480848 - is in Phase III trials for the treatment of Atherosclerosis.
  
• Successfully formed close and highly effective transnational interactions with the many groups and disciplines that programme leadership / co-ordination requires.
  
• Extensive direct therapeutic experience includes Atherosclerosis, Anti-virals, Schizophrenia, Hypertension, Arthritis, Pain and Asthma. Oversight of other areas including Stroke and Cardiovascular / Metabolic Syndrome.